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5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one

Mirodenafil

CAS: 862189-95-5

Molecular Formula: C26H37N5O5S

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  5. 5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one

5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one - Names and Identifiers

Name Mirodenafil
Synonyms MILONAFIL
MIRODENAFIL
Mirodenafil
5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one
5-Ethyl-2-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl}-2-propoxyphenyl)-7-propyl-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
5-Ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one
4H-Pyrrolo[3,2-d]pyriMidin-4-one,5-ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-
CAS 862189-95-5
EINECS 1533716-785-6

5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one - Physico-chemical Properties

Molecular FormulaC26H37N5O5S
Molar Mass531.67
Density1.33
Boling Point730.4±70.0 °C(Predicted)
pKa14.96±0.10(Predicted)

5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one - Reference Information

PDE5 inhibitor erectile dysfunction (erectile dysfunction,ED) is a common disease, which not only affects the quality of life, but also affects the relationship between patients and sexual partners. The emergence of type 5 phosphodiesterase inhibitors (phosphodiesterase type 5 inhibitors,PDE5Is) has completely changed the treatment of ED. Oral PDE5Is is the first-line treatment for ED regardless of the cause.
sildenafil (sildenafil), vardenafil (vardenafil), taralafil (tadalafil) and avanafil (avanafil) have been approved worldwide for ED treatment. Thirteen countries have approved udinafe (udenafil) for ED. Milonafe (Mirodenafil) is the second generation of PDE5I, which appeared in South Korea in 2007, called Mvix, and in December 2011 appeared oral instant film preparation (orally dissolving film), called Mvix S. Milonafe is only approved for the treatment of ED in South Korea. Its time to reach the peak plasma concentration (Tmax) is 1.25 hours and its half-life is 2.5 hours. Miloifem has 50 mg and 100mg, with side effects up to 53.7%, which are mild or systemic side effects. The most common side effects are headache (1.8-14.8%) and flushing (6.7-24.1%). Milonana was not tolerated better than several other PDE5Is. For ED complicated with hypertension or ED complicated with lower urinary tract symptoms (LUTS) and ED complicated with benign prostatic hyperplasia (BPH), antihypertensive drugs or α1-blockers should be used, and milonafil should be used at the same time. It is also safe, effective and well tolerated.
Last Update：2024-04-09 19:05:07
5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one
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HUBEI VANZPHARM INC.
Product Name: MIRODENAFIL Request for quotation
CAS: 862189-95-5
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HUBEI VANZPHARM INC.
Product Name: MIRODENAFIL Request for quotation
CAS: 862189-95-5
Tel: 027-84492310
Email: 3289009880@qq.com
Mobile: 18171127676
QQ: 3289009880 Click to send a QQ messageSend QQ message
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5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one
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